The #1 Lion's Mane Superfood


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Lion’s Mane Drug Interactions

We looked at the latest studies on lion’s mane mushroom and its interactions with prescription drugs. While lion's mane is perfectly safe for most people, it may interact with certain diabetes and blood thinning medications

Let's dive into the potential benefits, side effects, and drug interactions of this mushroom. And, for those looking to learn more about this amazing fungus, our lion's mane mushroom guide is a great place to start.

Article Jumplinks:

What are the health benefits of lion's mane?

Does lion's mane have spiritual benefits?

Does lion's mane interact with any medications?

Does lion's mane interact with blood thinners?

Does lion's mane interact with antiplatelets?

Does lion's mane interact with diabetes medication?

Can you take lion's mane with antidepressants?

Who should not take lion's mane?

How can you take lion's mane?

How much lion's mane mushroom is in Forij granola?

Lion’s Mane Mushroom

The lion's mane medicinal mushroom (Hericium erinaceusgoes by many names, including monkey head and Santa’s beard.

Due to their antioxidant activity and health benefits for both the body and the mind, lion’s mane fungi have remained popular adaptogenic mushrooms for centuries, being used in traditional Chinese medicine in the form of mushroom tea, as well as modern alternative medicine in the form of supplements and mushroom extracts.

Health Benefits of Lion’s Mane

Research on the health benefits of lion’s mane indicates the mushroom has significant potential to promote neurogenesis (nerve growth) and to prevent and repair nerve damage. Lion’s mane mushrooms seem to have protective effects on the brain, as they appear to improve overall mental function and alleviate neuropathic pain, among other neurological effects. 

Hericium erinaceus seems to aid children and adults in:

  • reducing depression and anxiety
  • reversing mild cognitive impairment
  • protecting against dementia and Alzheimer’s disease
  • reducing inflammation and nerve pains
  • encouraging apoptosis of cancer cells
  • speeding recovery of nervous system injuries
  • lowering blood sugar levels
  • reducing symptoms of neurodegenerative diseases, such as Parkinson’s disease, and multiple sclerosis

Lion's Mane Spiritual Benefits

Lion's mane mushrooms appear to have spiritual benefits. Shaolin monks in ancient China used the lion's mane mushroom in daily practice to improve their concentration. They believed it increased their "Qi," a mystical, energetic life force. Lion's mane's bioactive compounds do indeed seem to improve focus and memory.

Does Lion’s Mane Interact With Any Medications?

Lion's mane mushrooms may interact with prescription medications that slow down blood clotting (antiplatelet and anticoagulant drugs). The mushroom can have antiplatelet and antihyperglycemic effects, so lion's mane may be contraindicated for you if you're on antidiabetics or medication that slows blood clotting.

Lion’s Mane and Anticoagulants Interaction

Hericium erinaceus mushroom extracts were shown to have an inhibitory effect on collagen-induced platelet aggregation. Since platelet aggregation is responsible for blood clotting, the extract of Hericium erinaceus could slow down the body’s ability to make blood clots.

While this shouldn’t cause any issues and could even be beneficial for normal, healthy individuals, those who are already on blood-thinning medications, which also slow down blood clotting, may experience issues such as slower wound healing and more bruising if they start taking lion’s mane mushroom extracts.

Some of the most common anticoagulants (blood thinning medication) are:

  • heparin
  • warfarin
  • apixaban
  • rivaroxaban

Lion’s Mane and Antiplatelets

Due to the potential antiplatelet effect of Hericium erinaceus, people who are already on antiplatelet medication should use the mushroom with caution. Antiplatelet medication has a similar effect to blood thinners and is often prescribed by healthcare professionals to slow down the body’s ability to make clots.

Some of the most common antiplatelet medications are:

  • acetylsalicylic acid (Aspirin, Novasen, Entrophen, etc.)
  • clopidogrel
  • ticagrelor
  • prasugrel

Lion’s Mane and Antidiabetics

According to an animal study on the effects of lion’s mane supplements on diabetic rats, the activity of aqueous extract lion's mane mushroom supplements seems to include antihyperglycemic potential. Although there are no studies on the effects of lion’s mane extracts on people with diabetes, people who are on antidiabetics should be cautious when taking the mushroom.

Both antidiabetic medications and lion’s mane mushrooms lower blood sugar levels, so you may lower your blood sugar more than you expected if you take both at the same time. In order to prevent this, make sure to check your blood sugar levels frequently if you plan on taking extracts of Hericium erinaceus.

Lion's mane and antidiabetics

The most common antidiabetic medication includes:

  • insulin
  • metformin
  • glimepiride
  • invokana

Lion’s Mane Interactions with Antidepressants

Hericium erinaceus is known for its cognitive function and overall brain health benefits. One of the many benefits of lion’s mane for the mind is the mushroom’s ability to ease mild anxiety and depressive disorders.

double-blind, placebo-controlled study examined the effects of fruiting bodies of Hericium erinaceus on symptoms of depression, and the results show that the participants who were taking lion’s mane dietary supplements showed fewer signs of depression after 4 weeks.

So lion's mane helps depression, but does it interfere with antidepressants? Although more research is needed, so far, no studies suggest that lion’s mane use can reduce or increase the effects of antidepressants. Still, if you want to try the alternative medicine route in addition to traditional antidepressants, make sure to consult a healthcare provider.

Lion's Mane Side Effects

The centuries of use and the research by professional medical reviewers seem to suggest that lion’s mane doesn't have any serious potential side effects.

However, due to insufficient evidence on the effects of this medicinal mushroom on pregnancy and newborns, we don’t advise taking it if you’re trying for a baby. Some people also choose not to take lion's mane while breastfeeding.

Additionally, be cautious when taking lion’s mane if you have a bleeding disorder or are scheduled for surgery, as the mushroom might increase the chances of adverse effects such as bruising and bleeding due to its antiplatelet effects.

Who Should Not Take Lion's Mane?

Lion's mane mushrooms are generally safe for most people. However, if you are allergic or sensitive to mushrooms or experience mushroom allergies, you should avoid lion's mane. If you notice any signs of an allergic reaction (a skin rash or difficulty breathing), stop taking lion's mane and contact a healthcare professional.

Is Lion's Mane Psychedelic?

No, lion’s mane is not a psychedelic and can’t get you high. Mushrooms that can cause a high contain a compound called psilocybin, a naturally occurring psychedelic that can alter your state of mind.

As lion’s mane does not contain psilocybin or other psychoactive compounds, there is no risk of you getting high from consuming the fungus.

Interested in Trying Lion’s Mane?

Lion’s mane is generally safe for most people. Still, if you want to take lion’s mane and use any of the medications mentioned above, it’s best to consult with a medical professional before you start taking a supplement.

Forij Superfood Granola

Once your doctor gives you the green light,incorporate the helpful mushroom into your diet with ourForij Superfood Granola. In addition to a hyperconcentrated extract of lion’s mane, our granola contains extracts ofchaga andcordyceps mushrooms.

The granola is vegan, gluten-free, packed with nutrients,and delicious. What more could you want in a morning bowl of cereal?

Lion’s Mane Drug Interactions FAQ

How much lion's mane mushroom is in Forij granola?

Forij granola uses a high-quality lion's mane extract made from whole medicinal mushrooms. Our dual extraction method extracts both water-soluble beta-glucans as well as alcohol-soluble triterpenes. Our decoction process breaks down indigestible chitin cell walls of the mushroom to get much more of these compounds out than ordinary processes do.

One serving of our granola provides 250 mg of hyperconcentrated lion's mane extract, which is eight times more concentrated than a regular lion’s mane mushroom powder. Therefore, you get as much lion's mane potency as you would if you were taking a 2000 mg lion's mane powder supplement, all in one bowl of granola.

Is lion’s mane good for the lungs?

Animal research suggests that lion’s mane may be quite beneficial for the lungs. An in vitro study examined the effects of the Hericium erinaceus mycelium on cancer metastasis to the lung cells. The results show that the mushroom extract inhibited metastasis of cancer cells to the lung in mice.

Can lion’s mane cause stomach ulcers?

No, lion’s mane does not cause stomach ulcers. Quite the contrary, the lion's mane medicinal mushroom seems to improve digestive health and have gastroprotective properties, and it may even protect against ulcers, according to an animal study.

Can lion’s mane help with sleep disorders?

Research suggests that lion’s mane supplements may improve sleep quality, especially in sleep disorders caused by acute stress. A study examined the effects of Hericium erinaceus on insomnia caused by exam-related stress in students. Compared to the control group, students who took the supplement reported feeling less anxious and having fewer sleepless nights after 4 weeks.

Do mushroom supplements interact with medications?

Yes, certain mushroom supplements can interact with medications. For example, supplements that contain the reishi mushroom can interact with medication that treat high blood pressure, since this mushroom has blood pressure lowering properties. 

Certain medication can also interact with lion's mane mushrooms. These mushrooms may interact with blood clotting and anti-diabetes medication. However, they don't appear to interact with depression medication.

Can lion's mane cause anxiety?

No, lion's mane does not cause anxiety. Moreover, lion's mane may help alleviate symptoms of anxiety disorders. In addition to its ability to make you feel more relaxed and focused, Hericium erinaceus mushroom extracts may be able to improve sleep problems, a common symptom of anxiety disorders.

Should you take lion's mane before bed?

You should avoid taking lion's mane before bed. Extracts of Hericium erinaceus were shown to have memory-boosting properties, so it's best to take these mushrooms in the morning or early afternoon to reap the benefits throughout your work day. Taking lion's mane before bed may make you feel restless and unable to fall asleep.

Can lion's mane treat Parkinson's disease?

Lion's mane could be beneficial for Parkinson's disease patients. This mushroom was shown to promote nerve cell growth, and Parkinson's disease is caused by nerve cell degeneration. As there are no adverse effects to taking lion's mane and its evidence based benefits for Parkinson's patients, it's advisable to start taking this fungus as a way to prevent and treat Parkinson's disease.

What is the best lion's mane dosage for neuropathy?

Lion’s mane mushrooms have the potential to alleviate neuropathic pain. To reap these benefits, it's best to take about 500-1000 mg of Hericium erinaceus 1-3 times a day. The exact dosage will differ from person to person, so you should experiment until you find the perfect dosage for you.

Does lion's mane mushroom affect blood pressure?

Yes, the lion's mane mushroom can affect blood pressure. Specifically, this mushroom may lower blood pressure in people with high blood pressure. By lowering blood pressure, lion's mane alleviates the strain your heart has to go through to pump blood, thus preventing heart disease in the long run.

Can I take reishi and lion's mane together?

Yes, you can take lion’s mane with any medicinal mushroom, including cordyceps, turkey tail mushroom, maitake mushroom, and reishi mushroom. When it comes to medicinal mushrooms, the whole is better than the sum of its parts, so you’ll likely reap more benefits of lion’s mane if you take it with any other adaptogenic fungus, and even herbs (such as St. John's Wort).

Can I take lion's mane with caffeine?

Yes, you can take lion's mane mushrooms with caffeine. These mushrooms don't contain caffeine, so you don't run the risk of over-caffeinating and getting anxious or jittery. On the contrary, lion's mane may subside some of these negative effects of lion's mane (for example, Hericium erinaceus may alleviate migraines, a common side effect of caffeine consumption).

Does lion's mane work?

According to research, yes, lion's mane seems to work at alleviating symptoms of both physical and mental health conditions. Even athletes take lion's mane to feel more alert, focused, and energized during workouts.

Forij Disclaimer

This article was written strictly for informational purposes and is not intended to inform about medical advice, diagnosis, or treatment of any kind. The statements contained herein have not been evaluated by the Food and Drug Administration (FDA).

20 Responses



February 04, 2024

My sister has memory loss and she is taking fluoxetine for anxiety and cholesterol medication can she take lions mane capsules. Thank you



January 27, 2024

I am in the process of getting my thyroid meds regulated.Would lions mane upset the process?

Hermin Swaby

Hermin Swaby

January 08, 2024

My daughter is taking risperidone, is it safe to take Lion’s Mane with this drug



December 16, 2023

My husband is on epilim 1500 a day (anti-seizure meds) and I am on fluoxetine. Is it safe for us to use Lions mane?

Jacqueline oung

Jacqueline oung

November 26, 2023

Can I take lions mane with 20mg of Atorvastatin

Mrs S McDowell

Mrs S McDowell

November 22, 2023

I was recently taking higher doses than recommended of liquid Lions Mane. I am also on HRT. Around that time I experienced disregulated moods, anger, tearfulness and reactive behaviour. I also had to urinate much more than normal.
Could the ingestion on Lions Mane interfere with my HRT medication?

Antonia bishop

Antonia bishop

November 09, 2023

My mum has just been diagnosed with Alzheimer’s she is also on apixoban for blood thinning . Could lions mane be taken as an alternative to her blood thinner as I would like her to try and get some cognitive benefit from taking it



October 26, 2023

My husband has short term memory loss. He takes Memantine 10 mg twice a day and Losartan potassium 25mg once a day and fluoxetine 20 mg once a day.
Is it okay for him to have one teaspoon per day of Lions Mane with these meds?

Margaretta Davies

Margaretta Davies

October 05, 2023

I take methotrexate, celecoxib , oxycodone , amlodopine, sertraline atorvastatin and omeprazole for rheumatoid arthritis, high blood pressure and depression can I take lion’s mane or turkey tale or both please .?

Melissa Duffy

Melissa Duffy

September 22, 2023

I am taking Venlafaxine 225 mg a day, also 1 mg of Lorazepam 3 times a day. Can you take Lions Mane with these.

Bernadette J Murphy

Bernadette J Murphy

September 16, 2023

Can Lion’s Mane be used if one is taking statins for cholesterol?

Cheryl Williams

Cheryl Williams

September 12, 2023

My husband is taking medication for psoriatic arthritis- methotrexate and folic acid . He has been diagnosed with cognative impairment so I would like him to take Lions Mane , he has no problems with blood pressure or blood thinning so i assume it would be ok to take?

Mary Carlson

Mary Carlson

August 23, 2023

I take Lamota Jen for seizures. Can I take this?

Charmaine Vincent

Charmaine Vincent

August 21, 2023

I am taking one capsule of Noolit Lion’s mane strees reflief per day in the mornings together with 5mg of Lexamil and 5mg of tranquipam will the Lexamil and Tranquipam interfere with the Noolit?

Charmaine Vincent

Charmaine Vincent

August 21, 2023

I am taking one capsule of Noolit Lion’s mane strees reflief per day in the mornings together with 5mg of Lexamil and 5mg of tranquipam will the Lexamil and Tranquipam interfere with the Noolit?

Mary Jo Bankard

Mary Jo Bankard

May 16, 2023

I have a similar question that Gina asked. Can my husband take Lion’s mane if he is on memantine?

Mary Jo Bankard

Mary Jo Bankard

May 16, 2023

Asking for my husband. He has mild dementia. Some aphasia. He is also on Plavix, 75 mg. once a day. He already bruises fairly easily. Would it be dangerous for him to take Lion’s mane? I hear that it can help with cognition. That would be great. I guess I should ask his doctor if he could go off of Plavix for awhile to see if Lion’s Mane works? He is on plavix because of the embolic stroke that he had two years ago.



April 23, 2023

Can I take lions main with venlafaxine ?



April 15, 2023

I am on a lot of medication for mental health issues would I have to stop taking the medication to try lions mane?
I am currently on Ritalin, venaflaxine and quietiapine for my mental health I also have fibromyalgia and am looking for an alternative to pharmaceuticals

Gina Pastorino-Stemler

Gina Pastorino-Stemler

March 16, 2023

Can you take Lions Mane with dementia medications, mamantine and donepezil?

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About the Author

Meet Parker Olson, Founder of Forij.