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Taking Lion’s Mane for ALS: Does Hericium Erinaceus Help

Lion’s mane is an alternative medicine staple and one of the healthiest mushrooms in the world. One of its many benefits is the ability to repair damaged nerve cells and promote neurite outgrowth. This can be incredibly beneficial in managing ALS. Let’s dive into the benefits of lion’s mane for ALS.

Article Jumplinks:

What are the health benefits of lion’s mane?

What are the negative effects of lion's mane?

How does the lion’s mane mushrooms help ALS?

Can lions mane regrow brain cells?

Does lion's mane repair neurons?

How can I take lion’s mane for ALS?

How much lion’s mane should I take for ALS?

How much lion’s mane is in Forij granola?


To learn more about this amazing fungus, take a look at our lion’s mane mushroom guide.

What Are Lion’s Mane Mushrooms?

The adaptogenic mushroom lion's mane (Hericium erinaceus) has long been used in alternative medicine. It grows best in temperate to cool climates and is native to North America, northern Europe, and Asia.

To learn more about how lion's mane and other adaptogenic mushrooms work, read our detailed explanation on adaptogenic fungi.

Health Benefits of Lion’s Mane

The health benefits of lion’s mane mushrooms range from reducing inflammation and oxidative stress and aiding the immune system to managing mental health conditions such as anxiety and depression.

In clinical trials on the effects of Hericium erinaceus on neurodegenerative health conditions, this mushroom:

If you’d like to learn more about the beneficial effects this alternative medicine staple can have on various health conditions, read our article about the health benefits of lion’s mane.

Hericium erinaceus

Lion’s Mane Side Effects

Supplementing with lion's mane mushrooms has no long-term negative effects. If you're new to adaptogens, you may experience some gastric discomfort, bloating, or diarrhea at first, but these side effects should subside after a few days.

What Is ALS?

Amyotrophic lateral sclerosis (ALS) is a rare progressive motor neuron disease. It affects nerve cells that control voluntary muscle movement such as walking, chewing, and talking. In recent years, due to ALS awareness efforts, ALS research has become more prominent, but there is still no cure for this disease.

How Does Lion’s Mane Mushroom Help ALS?

As of 2023, no clinical ALS research has been done involving lion’s mane mushrooms. However, clinical trials on the effects of lion’s mane on neurite outgrowth and nerve repair show promising results when it comes to using this mushroom to manage ALS symptoms. Lion’s mane appears to help alleviate muscle twitches, cramps, stiffness, and muscle weakness, which are common symptoms of ALS. 

Lion’s Mane Neurogenesis Study

Lion’s mane appears to promote neurogenesis by increasing the production of nerve growth factors (NGF).

An in vitro study suggests that one of the lion's mane mushroom's properties is its ability to promote neurite outgrowth in PC12 cells. Bioactive compounds isolated from Hericium erinaceus fruit bodies increased the presence of nerve growth factor proteins in these cells significantly.

Human clinical trials (such as a double-blind, placebo-controlled study on the effects of Hericium erinaceus on mild cognitive impairment) show promising results, but the body of evidence isn't strong enough to say that lion's mane promotes the growth and regeneration of nerve cells in humans.

To learn more about the effects of lion’s mane on neurite outgrowth, check out our article on the effects of lion’s mane mushrooms on neurogenesis.

Lion's mane for ALS

Lion’s Mane Study on Nerve Repair

2011 animal study looked into the potential of lion's mane mushrooms for nerve repair. Rats with peripheral nerve damage were given an oral extract from the fresh fruit bodies of lion's mane in this study.

The results show that function recovery was significantly faster in rats given lion's mane extracts than in the control group, as measured by a walking track analysis.

Though more research on human nerve fiber injuries is needed, this study suggests that the activity of lion's mane aqueous extract prevents further injury and accelerates nerve healing, at least in animal nervous systems.

Lion’s Mane Motor Neuron Disease Benefits

Health conditions such as ALS, Parkinson’s disease, multiple sclerosis, and other motor neuron diseases are caused by progressive damage to nerve cells. Lion’s mane appears to promote nerve cell growth and regeneration through the production of nerve growth factors (NGF). This effect is responsible for the apparent benefits of lion's mane for motor neuron diseases.

While there is no cure for most motor neuron diseases, there are ways to slow down their progression and even repair some of the damage caused by the ailment. That’s where lion’s mane comes in. This mushroom appears to have the opposite effect on the brain as neurodegenerative diseases, making it a promising adaptogen to take for motor neuron disease management.

How Can You Start Taking Lion’s Mane for ALS

If you want to start taking lion's mane to manage ALS, you should start with the best supplement on the market. And, at the risk of sounding biased, our medicinal mushroom granola has exactly what you're looking for.

Our granola contains a high-quality, hyperconcentrated lion's mane extract that contains all of the beneficial compounds found in this mushroom (including those that you can't get from eating fresh lion's mane).

The granola is vegan, gluten-free, made with nutritious ingredients, and delicious. What more could you want from a morning bowl of granola?

Forij superfood granola

Lion’s Mane Dosage for ALS

The exact lion’s mane mushroom dosage for ALS differs from person to person. If you’re new to adaptogens, it’s best to start with a dose of 750-1000 mg, as to avoid digestive discomfort. Once you get used to lion’s mane, you can increase the dosage to 2000 mg or more, until you are happy with its effects.

How Much Lion’s Mane Is in Forij Granola?

Forij granola uses high-quality lion's mane extracts made from whole medicinal mushrooms. Our dual extraction method extracts both water-soluble beta-glucans as well as alcohol-soluble triterpenes. Our decoction process breaks down indigestible chitin cell walls of the mushroom to get much more of these compounds out than ordinary processes do.

One serving of our granola provides 250 mg of hyperconcentrated lion's mane mushroom extract, which is eight times more concentrated than regular lion’s mane dietary supplementation. Therefore, you get as much lion's mane potency as you would if you were taking a 2000 mg mushroom powder supplement, all in one bowl of granola.

FAQ on Lion’s Mane for ALS

Can lion’s mane cause nerve damage?

No, lion's mane does not cause nerve damage. This mushroom appears to help prevent nerve damage associated with neurodegenerative diseases, such as multiple sclerosis and Alzheimer’s disease, and aid in nerve recovery. Lion's mane also relieves neuropathic pain, which is a common symptom of nerve damage.

Does lion’s mane grow new nerves?

While lion’s mane does not grow new nerves on its own, it appears to stimulate our brain to grow nerves. Contrary to popular belief, the human brain grows new nerve cells throughout its whole life, and lion’s mane medicinal mushrooms seem to aid in this process.

Does lion’s mane work immediately?

The full effects of Hericium erinaceus should be felt within the first two weeks of taking lion's mane supplements. However, don't be discouraged if you don't see immediate results. Try different doses of lion's mane until you find one that makes you feel good, and you'll notice its many benefits within a month or so.

Who should not take lion’s mane mushrooms?

Although most people are safe to use lion's mane, it does have some contraindications. If you have a history of allergies or are allergic to mold, yeast, or other fungi, you should use lion's mane or another adaptogenic mushroom with caution.

Some medications, such as diabetes medications, may also interact with lion's mane. If you are taking any medications that may interact with lion's mane, you should consult your doctor for medical advice before taking Hericium erinaceus.

What does lion’s mane cure?

No mushroom, including lion’s mane, can cure a disease on its own. However, this mushroom appears to aid in the treatment of many health conditions, including Parkinson’s disease, Alzheimer’s disease, and multiple sclerosis.

The medicinal mushroom Hericium erinaceus can also aid in reducing inflammation and oxidative stress, improving the immune system, and even ease symptoms of mental health conditions such as anxiety and depression.

Does lion’s mane increase dopamine?

Although lion's mane medicinal mushrooms do not appear to increase dopamine, they do appear to stabilize dopamine levels in animals. This effect is likely behind the beneficial effects lion’s mane can have on depression.

2018 animal study investigated the underlying mechanisms of the antidepressant effects of lion’s mane mushroom extract in mice. The findings suggest that when the mice were stressed, their dopamine levels dropped.

Their dopamine levels stabilized after taking lion's mane extracts, despite no changes in their stress levels. This suggests that lion's mane may be to blame for the increase in dopamine levels, though more human research is required to fully comprehend this lion's mane benefit.

Can lion’s mane be taken long term?

Taking lion's mane mushrooms long term is not only completely safe, but extremely beneficial. Long-term benefits of lion's mane, such as improved cognitive functioning and the ability to alleviate Parkinson's disease symptoms, become more apparent the longer you use this mushroom.

Is lion’s mane addiction possible?

No, even if taken daily, lion's mane mushrooms are not addictive. Even if you're taking high doses of lion's mane, you won't experience any side effects or withdrawal symptoms if you stop taking it, but you will stop reaping its benefits.

When is ALS awareness day?

ALS awareness day is on the 21st of June..


  1. Lai, P. L. (2013). Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. International Journal of Medicinal Mushrooms, 15(6), 539–554.
  2. Zhang, C. C. (2015). Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth on PC12 cells. Bioorganic & Medicinal Chemistry Letters, 25(22), 5078–5082.
  3. Mori, K. (2009). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytotherapy Research, 23(3), 367–372.
  4. Wong, K. H. (2011). Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae). Evidence-Based Complementary and Alternative Medicine, 2011, 1–10.
  5. Chiu, C. H. (2018). Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice. International Journal of Molecular Sciences, 19(2), 341.

Forij Disclaimer

This article was written strictly for informational purposes and is not intended to provide medical advice or diagnose, treat, cure, or prevent any disease. The statements contained herein have not been evaluated by the Food and Drug Administration (FDA) and should not be used for medicinal purposes.

4 Responses

kenneth wilson

kenneth wilson

August 23, 2023

My brother David has been diagnose with ALS for a little more than a year. He showed signs of it for close to three years and no Doctor was able to figure out what was wrong, until my sister whom he had been living with kept trying to bring him to each doctor -- finally found a doctor who recognised almost immediately that he had ALS. He has been taking medication that was made available to him only through a medical grant funding from those who have donated to the continuing research for a possible cure. He has slowed down in the progression, but without side affects. My hopes and prayers are that, you can also contact the Doctor for possible cure if you have ALS or any relative suffering for same disease here is their email Website:



July 18, 2023

I was diagnosed with HPV which they said there is no cure for this virus. but I’m surprised that after taking Dr IBOZUA herbs i got cured out of it. and also I have referred a lot of people to this herbal medical doctor for a cure and he has never failed. Here is dr IBOZUA information whatsapp him +2348109374702 or his email address:

Mateo Pedro

Mateo Pedro

June 30, 2023

My Dad was diagnosed with MND ALS (amyotrophic lateral sclerosis) when he was 57 years old 4 years ago. He was progressing at the speed of light. His significantly worse every single day The riluzole did very little to help him. The medical team did even less. His decline was rapid and devastating. The psychological support from the medical center was non-existent and if it were not for and the sensitive cure of their herbal formula he would have been not been alive today, there was a significant improvement in the first 4 weeks of usage that gave us hope that he will be alive, His doctor put him on riluzole, letting us know there was no cure until we gave try on Madiba herbal supplement that cure him totally from this disease after 13 weeks of his usage. There is nothing positive about the cure for ALS condition except for the herbal remedies from that company.

Veronica McKall

Veronica McKall

March 20, 2023

My grandma who has been Lou Gehrig’s disease for 2 years at the age of 75 had all her symptoms reversed with a Ayurveda medicine from health natural centre . org after undergoing their ALS natural treatment plan. God Bless all ALS Caregivers. Stay Strong, take small moments throughout the day to thank yourself, to love your self, and pray to whatever faith, star, spiritual force you believe in and ask for strength. I can personally vouch for these remedy but you would probably need to decide what works best for you.

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About the Author

Meet Parker Olson, Founder of Forij.